Guidance Documents

The following guidance documents have been published in peer-reviewed literature. They relate to the specifics for human health and environmental effects evaluations as well as to IFRA procedures on how to provide estimates of consumer exposure to fragrance ingredients. They are also mentioned in Appendix 5 (Safety Evaluation of Fragrance Materials) of the IFRA Code of Practice.

1. Human Health Evaluation

Evaluation of the potential effects of fragrance materials on the skin, for irritation and sensitization, as well as sunlight-mediated effects, systemic toxicity, etc., should utilize the Human Health Criteria Document which has been published as:

 “Criteria for development of a database for safety evaluation of fragrance ingredients”, R.A. Ford, B. Domeyer, O. Easterday, K. Maier, and J. Middleton, Regulatory Toxicology and Pharmacology, 31: 166-181 (2000).
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2. Environmental Effects

A methodology for conducting a preliminary aquatic risk assessment for fragrance materials can be found in the Environmental Framework Document which has been published as:

“A framework for prioritizing fragrance materials for aquatic risk assessment”, D.T. Salvito, R.J. Senna, and T.W. Federle, Environmental Toxicology and Chemistry, 21(3): 1301-1308 (2002).
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3. Safety Assessment of Fragrance Materials

A description of the process applied for fragrance material safety evaluation by the RIFM Expert Panel has been published as:

 “The safety assessment of fragrance materials”, D.R. Bickers, P. Calow, H.A. Greim, J. M. Hanifin, A. E. Rogers, J.H. Saurat, I.G. Sipes, R.L. Smith and H. Tagami, Regulatory Toxicology and Pharmacology, 37: 218-273 (2003).
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4. Exposure Assessment

A description on how fragrance industry’s procedures for estimating exposure to fragrance ingredients through different routes and leading to different potential endpoints has been published as:

“Consumer exposure to Fragrance Ingredients: Providing Estimates for Safety Evaluation”, P.A. Cadby, W.R. Troy, and M.G.H. Vey, Regulatory Toxicology and Pharmacology, 36: 246-252 (2002).
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